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What is DoxyPEP?

Doxycycline for post-exposure prophylaxis, or DoxyPEP, is a new way to prevent sexually transmitted diseases (STDs) like syphilis, gonorrhea, and chlamydia.

The name "DoxyPEP" is a combination of two words:

  • Doxycycline ("Doxy-") is an antibiotic doctors have safely used to treat many bacterial infections since 1967.
  • Post-exposure prophylaxis ("-PEP") is a medicine someone takes after exposure to stop infections before they start.

Taking DoxyPEP is easy.  It is two pills taken by mouth within 72 hours after having sex. It can reduce your chances of getting syphilis and chlamydia by up to 70 percent and gonorrhea by up to 50 percent. DoxyPEP cannot protect against viral STDs like herpes, human papillomavirus (HPV), or HIV.

患者信息

Can I take DoxyPEP?

Talk to your health care provider about DoxyPEP as an option for protecting yourself from STDs when you have sex.

Getting DoxyPEP

Visit a health care provider to get a prescription for Doxy PEP. DoxyPEP is a new way of treating STDs, so your provider might not have heard about it yet.

Find DoxyPEP near you.

Steps to Getting DoxyPEP

Make an appointment to see your health care provider to get a prescription. Before prescribing DoxyPEP, your provider should:

  • Test you for any STDs such as syphilis, gonorrhea, chlamydia, and HIV.
  • Talk to you about combining DoxyPEP with other ways of protecting yourself from STDs, like:
    • Condoms,
    • Reducing sexual partners, or
    • Pre-exposure prophylaxis (PrEP) for HIV.
  • Talk to you about side effects, interactions with other drugs, and the need for further testing.
  • Tell you when to return to the clinic for STD testing.

Provider Information

CDC Releases DoxyPEP Guidelines

On June 6, 2024, the Centers for Disease Control and Prevention (CDC) published the CDC Clinical Guidelines on the Use of Doxycycline Post-Exposure Prophylaxis for Bacterial Sexually Transmitted Infection Prevention.

The CDC endorses DoxyPEP as the first new STD prevention tool in decades. DoxyPEP is the self-administration of 200 mg of doxycycline within 72 hours after sex to prevent bacterial STD acquisition. DoxyPEP has proven to reduce the risk of getting a bacterial STD for syphilis, chlamydia and gonorrhea.

Fact Sheet for Providers

臨床資源

Some of these resources were created before the publication of the CDC guidelines. Providers should tailor all clinical protocols and educational materials to fit the needs of their local communities while considering the most current CDC guidelines.

CDC 指南

Podcasts and Webinar Recordings

其他資源