{"id":14455,"date":"2026-03-13T18:33:35","date_gmt":"2026-03-13T18:33:35","guid":{"rendered":"https:\/\/www.vdh.virginia.gov\/disease-prevention\/?page_id=14455"},"modified":"2026-04-14T17:13:53","modified_gmt":"2026-04-14T17:13:53","slug":"doxypep","status":"publish","type":"page","link":"https:\/\/www.vdh.virginia.gov\/disease-prevention\/doxypep\/","title":{"rendered":"DoxyPEP"},"content":{"rendered":"<div id=\"pl-14455\"  class=\"panel-layout\" ><div id=\"pg-14455-0\"  class=\"panel-grid panel-has-style\" ><div class=\"panel-row-style panel-row-style-for-14455-0\" ><div id=\"pgc-14455-0-0\"  class=\"panel-grid-cell\" ><div class=\"panel-cell-style panel-cell-style-for-14455-0-0\" ><div id=\"panel-14455-0-0-0\" class=\"widget_text so-panel widget widget_custom_html panel-first-child\" data-index=\"0\" ><div class=\"textwidget custom-html-widget\"><style>\n   h1 {\n    color: #00245D;\n    font-size: 2.2rem;\n    font-weight: 700;\n    letter-spacing: -0.02em;\n    line-height: 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0;\n  }\n\n  .resources-block {\n    background-color: #f8fafd;\n    border: 1px solid #c8d3e8;\n    border-radius: 11px;\n    box-shadow: 0 2px 6px rgba(0, 36, 93, 0.07);\n    margin: 0 0 1.5rem 0;\n    padding: 1.5rem 1.75rem;\n\t\tmax-width: 55rem;\n  }\n\n  .resources-block h2:first-child,\n  .resources-block h3:first-child {\n    margin-top: 0;\n  }\n\n  .resources-block h2,\n  .resources-block h3 {\n    margin-bottom: 1rem;\n  }\n\n  .resources-block ul {\n    list-style: none;\n    margin: 0;\n    padding: 0;\n  }\n\n  .resources-block ul li {\n    border-bottom: 1px solid #dce6f5;\n    color: #222222;\n    font-size: 0.975rem;\n    line-height: 1.6;\n    margin: 0;\n    padding: 0.6rem 0 0.6rem 1.25rem;\n    position: relative;\n  }\n\n  .resources-block ul li:last-child {\n    border-bottom: none;\n  }\n\n  .resources-block ul li::before {\n    content: '';\n    background-color: #1F70B8;\n    border-radius: 50%;\n    height: 6px;\n    left: 0;\n    position: absolute;\n    top: 50%;\n    transform: translateY(-50%);\n    width: 6px;\n  }\na.btn {\n  background-color: #00245D;\n  border: none;\n  border-radius: 6px;\n  box-shadow: 0 2px 5px rgba(0, 36, 93, 0.18);\n  color: #ffffff;\n  cursor: pointer;\n  display: inline-block;\n  font-size: 0.9rem;\n  font-weight: 600;\n  letter-spacing: 0.03em;\n  margin: 0;\n  padding: 0.5rem 1.1rem;\n  text-decoration: none;\n  transition: background-color 0.2s ease, box-shadow 0.2s ease;\n}\n\na.btn:hover {\n  background-color: #1F70B8;\n  box-shadow: 0 3px 8px rgba(0, 36, 93, 0.22);\n}\n\na.btn:active {\n  background-color: #001a45;\n  box-shadow: 0 1px 3px rgba(0, 36, 93, 0.18);\n  transform: translateY(1px);\n}\n\t\n<\/style><\/div><\/div><div id=\"panel-14455-0-0-1\" class=\"so-panel widget widget_sow-editor\" data-index=\"1\" ><div class=\"jump-nav panel-widget-style panel-widget-style-for-14455-0-0-1\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<ul>\n<li><a href=\"#patientinfo\">Patient Information<\/a><\/li>\n<li><a href=\"#providerinfo\">Provider Information<\/a><\/li>\n<li><a href=\"#clinicalresources\">Clinical Resources<\/a><\/li>\n<\/ul>\n<\/div>\n<\/div><\/div><\/div><div id=\"panel-14455-0-0-2\" class=\"so-panel widget widget_sow-editor\" data-index=\"2\" ><div class=\"content-block panel-widget-style panel-widget-style-for-14455-0-0-2\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h2>What is DoxyPEP?<\/h2>\n<p>Doxycycline for post-exposure prophylaxis, or DoxyPEP, is a new way to prevent sexually transmitted diseases (STDs) like syphilis, gonorrhea, and chlamydia.<\/p>\n<p>The name \"DoxyPEP\" is a combination of two words:<\/p>\n<ul>\n<li>Doxycycline (\"Doxy-\") is an antibiotic doctors have safely used to treat many bacterial infections since 1967.<\/li>\n<li>Post-exposure prophylaxis (\"-PEP\") is a medicine someone takes after exposure to stop infections before they start.<\/li>\n<\/ul>\n<p>Taking DoxyPEP is easy. \u00a0It is two pills taken by mouth within 72 hours after having sex. It can reduce your chances of getting syphilis and chlamydia by up to 70 percent and gonorrhea by up to 50 percent. DoxyPEP cannot protect against viral STDs like herpes, human papillomavirus (HPV), or HIV.<\/p>\n<\/div>\n<\/div><\/div><\/div><div id=\"panel-14455-0-0-3\" class=\"so-panel widget widget_siteorigin-panels-builder\" data-index=\"3\" ><div class=\"content-block panel-widget-style panel-widget-style-for-14455-0-0-3\" id=\"patientinfo\" ><div id=\"pl-w69b45828a767f\"  class=\"panel-layout\" ><div id=\"pg-w69b45828a767f-0\"  class=\"panel-grid panel-has-style\" ><div class=\"panel-row-style panel-row-style-for-w69b45828a767f-0\" ><div id=\"pgc-w69b45828a767f-0-0\"  class=\"panel-grid-cell\" ><div class=\"panel-cell-style panel-cell-style-for-w69b45828a767f-0-0\" ><div id=\"panel-w69b45828a767f-0-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h1>Patient Information<\/h1>\n<h2>Can I take DoxyPEP?<\/h2>\n<p>Talk to your health care provider about DoxyPEP as an option for protecting yourself from STDs when you have sex.<\/p>\n<h2>Getting DoxyPEP<\/h2>\n<p>Visit a health care provider to get a prescription for Doxy PEP. DoxyPEP is a new way of treating STDs, so your provider might not have heard about it yet.<\/p>\n<p><a class=\"btn\" href=\"https:\/\/finddoxypep.cdc.gov\/\"><strong>Find DoxyPEP near you.<\/strong><\/a><\/p>\n<h2>Steps to Getting DoxyPEP<\/h2>\n<p>Make an appointment to see your health care provider to get a prescription. Before prescribing DoxyPEP, your provider should:<\/p>\n<ul>\n<li>Test you for any STDs such as syphilis, gonorrhea, chlamydia, and HIV.<\/li>\n<li>Talk to you about combining DoxyPEP with other ways of protecting yourself from STDs, like:\n<ul>\n<li>Condoms,<\/li>\n<li>Reducing sexual partners, or<\/li>\n<li>Pre-exposure prophylaxis (PrEP) for HIV.<\/li>\n<\/ul>\n<\/li>\n<li>Talk to you about side effects, interactions with other drugs, and the need for further testing.<\/li>\n<li>Tell you when to return to the clinic for STD testing.<\/li>\n<\/ul>\n<\/div>\n<\/div><\/div><div id=\"panel-w69b45828a767f-0-0-1\" class=\"so-panel widget widget_sow-editor panel-last-child\" data-index=\"1\" ><div class=\"resources-block panel-widget-style panel-widget-style-for-w69b45828a767f-0-0-1\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h2>Fact Sheet for Patients<\/h2>\n<ul style=\"margin-bottom:0 !important;\">\n<li><a href=\"https:\/\/www.vdh.virginia.gov\/content\/uploads\/sites\/220\/2024\/02\/DoxyPEP-Factsheet-for-Patients.pdf\">DoxyPEP Fact Sheet for Patients - English<\/a><\/li>\n<li><a href=\"https:\/\/www.vdh.virginia.gov\/content\/uploads\/sites\/220\/2024\/02\/DoxyPEP-Factsheet-for-Patients-Spanish.pdf\">DoxyPEP Informaci\u00f3n para Pacientes - Espa\u00f1ol<\/a><\/li>\n<\/ul>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><div id=\"panel-14455-0-0-4\" class=\"so-panel widget widget_siteorigin-panels-builder\" data-index=\"4\" ><div class=\"content-block panel-widget-style panel-widget-style-for-14455-0-0-4\" id=\"providerinfo\" ><div id=\"pl-w69b45828b7515\"  class=\"panel-layout\" ><div id=\"pg-w69b45828b7515-0\"  class=\"panel-grid panel-has-style\" ><div class=\"panel-row-style panel-row-style-for-w69b45828b7515-0\" ><div id=\"pgc-w69b45828b7515-0-0\"  class=\"panel-grid-cell\" ><div class=\"panel-cell-style panel-cell-style-for-w69b45828b7515-0-0\" ><div id=\"panel-w69b45828b7515-0-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h1>Provider Information<\/h1>\n<h2>CDC Releases DoxyPEP Guidelines<\/h2>\n<p>On June 6, 2024, the Centers for Disease Control and Prevention (CDC) published the\u00a0<a href=\"https:\/\/www.cdc.gov\/mmwr\/volumes\/73\/rr\/rr7302a1.htm\">CDC Clinical Guidelines on the Use of Doxycycline Post-Exposure Prophylaxis for Bacterial Sexually Transmitted Infection Prevention<\/a>.<\/p>\n<p>The CDC endorses DoxyPEP as the first new STD prevention tool in decades. DoxyPEP is the self-administration of 200 mg of doxycycline within 72 hours after sex to prevent bacterial STD acquisition. DoxyPEP has proven to reduce the risk of getting a bacterial STD for syphilis, chlamydia and gonorrhea.<\/p>\n<\/div>\n<\/div><\/div><div id=\"panel-w69b45828b7515-0-0-1\" class=\"so-panel widget widget_sow-editor panel-last-child\" data-index=\"1\" ><div class=\"resources-block panel-widget-style panel-widget-style-for-w69b45828b7515-0-0-1\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h2>Fact Sheet for Providers<\/h2>\n<ul style=\"margin-bottom: 0 !important;\">\n<li><a href=\"https:\/\/www.vdh.virginia.gov\/content\/uploads\/sites\/220\/2024\/02\/DoxyPEP-Factsheet-for-Providers.pdf\">DoxyPEP Fact Sheet for Providers<\/a><\/li>\n<\/ul>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><div id=\"panel-14455-0-0-5\" class=\"so-panel widget widget_sow-editor panel-last-child\" data-index=\"5\" ><div class=\"resources-block panel-widget-style panel-widget-style-for-14455-0-0-5\" id=\"clinicalresources\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h1>Clinical Resources<\/h1>\n<p>Some of these resources were created before the publication of the CDC guidelines. Providers should tailor all clinical protocols and educational materials to fit the needs of their local communities while considering the most current CDC guidelines.<\/p>\n<h2><strong>CDC Guidelines<\/strong><\/h2>\n<ul>\n<li><a href=\"https:\/\/www.cdc.gov\/sti\/hcp\/doxy-pep\/index.html\">Doxy PEP for Bacterial STI Prevention<\/a><\/li>\n<li><a href=\"https:\/\/www.std.uw.edu\/page\/clinical-guides\/guides#doxy-pep\">Clinician\u2019s Information Guide: Doxy PEP for STI Prevention<\/a><\/li>\n<\/ul>\n<h2><strong>Podcasts and Webinar Recordings<\/strong><\/h2>\n<ul>\n<li><a href=\"https:\/\/www.zoomgov.com\/rec\/play\/zYunbdQjwarih1JMNG8br0lXXmUpWrzTM0nze44oQFQB2-V_5pQUhR8pcS9YA4rah2pn4HuKHkFCnFot.Gx0sfxGLMMsMHuDO\">HRSA -Tackling STIs and Syphilis Prevention with DoxyPEP<\/a><\/li>\n<li><a href=\"https:\/\/www.std.uw.edu\/podcast\/episode\/hot-topic\/new-proposed-guidelines-doxy-pep-key-points\">National STD Curriculum Podcast - New Proposed Guidelines DoxyPep<\/a><\/li>\n<li><a href=\"https:\/\/californiaptc.com\/training\/sti-expert-hour-webinar-on-doxycycline-post-exposure-prophylaxis-2\/\">California PTC-STI Expert Hour Webinar on DoxyPEP<\/a><\/li>\n<li><a href=\"https:\/\/youtu.be\/GzkY1iZuww0\">National Network of STD Clinical Prevention Training Center (NNPTC) Doxy PEP Clinical Update<\/a><\/li>\n<\/ul>\n<h2><strong>Other Resources<\/strong><\/h2>\n<ul>\n<li><a href=\"https:\/\/www.denverptc.org\/doxy-pep-resources\/\">Denver STD Prevention Training Center<\/a><\/li>\n<li><a href=\"https:\/\/www.ncsddc.org\/resource\/doxy-as-sti-pep-command-center\/\">National Coalition of STD Directors DoxyPEP Command Center<\/a><\/li>\n<\/ul>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Patient Information Provider Information Clinical Resources What is DoxyPEP? Doxycycline for post-exposure prophylaxis, or DoxyPEP, is a new way to prevent sexually transmitted diseases (STDs) like syphilis, gonorrhea, and chlamydia. The name &#8220;DoxyPEP&#8221; is a combination of two words: Doxycycline (&#8220;Doxy-&#8220;) is an antibiotic doctors have safely used to treat many bacterial infections since 1967. [&hellip;]<\/p>\n","protected":false},"author":344,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_lmt_disableupdate":"no","_lmt_disable":"","footnotes":""},"tags":[],"class_list":["post-14455","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>DoxyPEP - Disease Prevention<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.vdh.virginia.gov\/disease-prevention\/doxypep\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"DoxyPEP - Disease Prevention\" \/>\n<meta property=\"og:description\" content=\"Patient Information Provider Information Clinical Resources What is DoxyPEP? 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